Epidemiology and new developments in the diagnosis of prosthetic joint infection
Identifieur interne : 000578 ( France/Analysis ); précédent : 000577; suivant : 000579Epidemiology and new developments in the diagnosis of prosthetic joint infection
Auteurs : Stéphane Corvec [France] ; María E. Portillo [Espagne] ; Bruna Maria Pasticci [Italie] ; Olivier Borens [Suisse] ; Andrej Trampuz [Suisse]Source :
- International journal of artificial organs [ 0391-3988 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Although prosthetic joint infection (PJI) is a rare event after arthroplasty, it represents a significant complication that is associated with high morbidity, need for complex treatment, and substantial healthcare costs. An accurate and rapid diagnosis of PJI is crucial for treatment success. Current diagnostic methods in PJI are insufficient with 10-30% false-negative cultures. Consequently, there is a need for research and development into new methods aimed at improving diagnostic accuracy and speed of detection. In this article, we review available conventional diagnostic methods for the diagnosis of PJI (laboratory markers, histopathology, synovial fluid and periprosthetic tissue cultures), new diagnostic methods (sonication of implants, specific and multiplex PCR, mass spectrometry) and innovative techniques under development (new laboratory markers, microcalorimetry, electrical method, reverse transcription [RT]-PCR, fluorescence in situ hybridization [FISH], biofilm microscopy, microarray identification, and serological tests). The results of highly sensitive diagnostic techniques with unknown specificity should be interpreted with caution. The organism identified by a new method may represent a real pathogen that was unrecognized by conventional diagnostic methods or contamination during specimen sampling, transportation, or processing. For accurate interpretation, additional studies are needed, which would evaluate the long-term outcome (usually >2 years) with or without antimicrobial treatment. It is expected that new rapid, accurate, and fully automatic diagnostic tests will be developed soon.
Affiliations:
- Espagne, France, Italie, Suisse
- Canton de Vaud, Catalogne, Pays de la Loire
- Barcelone, Lausanne, Nantes
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Pascal:13-0079080Le document en format XML
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Portillo</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Microbiology, Reference Laboratory of Catalunya</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pasticci, Bruna Maria" sort="Pasticci, Bruna Maria" uniqKey="Pasticci B" first="Bruna Maria" last="Pasticci">Bruna Maria Pasticci</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Infectious Disease Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia</s1><s2>Perugia</s2><s3>ITA</s3><sZ>3 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Borens, Olivier" sort="Borens, Olivier" uniqKey="Borens O" first="Olivier" last="Borens">Olivier Borens</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Division of Orthopedic Surgery and Traumatology, Department of Surgery and Anesthesiology, University Hospital Lausanne</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Trampuz, Andrej" sort="Trampuz, Andrej" uniqKey="Trampuz A" first="Andrej" last="Trampuz">Andrej Trampuz</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital and University of Lausanne</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of artificial organs</title><title level="j" type="abbreviated">Int. j. artif. organs</title><idno type="ISSN">0391-3988</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of artificial organs</title><title level="j" type="abbreviated">Int. j. artif. organs</title><idno type="ISSN">0391-3988</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Complication</term><term>Diagnosis</term><term>Epidemiology</term><term>Fluorescence in situ hybridization</term><term>Human</term><term>Infection</term><term>Joint</term><term>Matrix assisted laser desorption ionization</term><term>Orthopedic surgery</term><term>Polymerase chain reaction</term><term>Prosthesis</term><term>Serology</term><term>Sonication</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prothèse</term><term>Epidémiologie</term><term>Complication</term><term>Diagnostic</term><term>Articulation</term><term>Infection</term><term>Sonication</term><term>Réaction chaîne polymérase</term><term>MALDI</term><term>Hybridation in situ fluorescence</term><term>Sérologie</term><term>Chirurgie orthopédique</term><term>Homme</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although prosthetic joint infection (PJI) is a rare event after arthroplasty, it represents a significant complication that is associated with high morbidity, need for complex treatment, and substantial healthcare costs. An accurate and rapid diagnosis of PJI is crucial for treatment success. Current diagnostic methods in PJI are insufficient with 10-30% false-negative cultures. Consequently, there is a need for research and development into new methods aimed at improving diagnostic accuracy and speed of detection. In this article, we review available conventional diagnostic methods for the diagnosis of PJI (laboratory markers, histopathology, synovial fluid and periprosthetic tissue cultures), new diagnostic methods (sonication of implants, specific and multiplex PCR, mass spectrometry) and innovative techniques under development (new laboratory markers, microcalorimetry, electrical method, reverse transcription [RT]-PCR, fluorescence in situ hybridization [FISH], biofilm microscopy, microarray identification, and serological tests). The results of highly sensitive diagnostic techniques with unknown specificity should be interpreted with caution. The organism identified by a new method may represent a real pathogen that was unrecognized by conventional diagnostic methods or contamination during specimen sampling, transportation, or processing. For accurate interpretation, additional studies are needed, which would evaluate the long-term outcome (usually >2 years) with or without antimicrobial treatment. It is expected that new rapid, accurate, and fully automatic diagnostic tests will be developed soon.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Italie</li><li>Suisse</li></country><region><li>Canton de Vaud</li><li>Catalogne</li><li>Pays de la Loire</li></region><settlement><li>Barcelone</li><li>Lausanne</li><li>Nantes</li></settlement></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Corvec, Stephane" sort="Corvec, Stephane" uniqKey="Corvec S" first="Stéphane" last="Corvec">Stéphane Corvec</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Portillo, Maria E" sort="Portillo, Maria E" uniqKey="Portillo M" first="María E." last="Portillo">María E. Portillo</name></region></country><country name="Italie"><noRegion><name sortKey="Pasticci, Bruna Maria" sort="Pasticci, Bruna Maria" uniqKey="Pasticci B" first="Bruna Maria" last="Pasticci">Bruna Maria Pasticci</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Borens, Olivier" sort="Borens, Olivier" uniqKey="Borens O" first="Olivier" last="Borens">Olivier Borens</name></region><name sortKey="Trampuz, Andrej" sort="Trampuz, Andrej" uniqKey="Trampuz A" first="Andrej" last="Trampuz">Andrej Trampuz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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